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KMID : 0616120080390040295
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 4 p.295 ~ p.299
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Antioxidant Activity and Cytotoxic Effect of Extracts from Euphorbia humifusa
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Heo Seong-Il
Hu Wei-Cheng
Han Woong
Wang Myeong-Hyeon
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Abstract
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The antioxidant activities, anti-inflammatory activity and cytotoxic effects of methanol extract from Euphorbia humifusa were evaluated in this study. Total phenolic compound contents were 68.35±0.16 mg/g and total flavonoid compound contents were estimated as 38.74±1.26 mg/g. EC50 values for DPPH radical scavenging activity of methanol extract was 56.26±0.66 μg/mL and those of positive controls as ascorbic acid, α-tocopherol and BHA were 8.38±0.14 μg/mL, 16.45±0.89 μg/mL and 21.18±1.01 μg/mL respectively. NO scavenging activity increased in depending on concentration of extract. Treatment of RAW 264.7 cells with extract caused inhibition of LPS-induced nitric oxide production. The cell viability showed that the methanol extract had cytotoxicity in the growth of breast cancer cell (66.54±1.91% at 400 μg/mL conc., 43.98±3.35% at 800 μg/mL conc.). Based on the results, It was suggested that the methanol extract of Euphorbia humifusa has a potential candidate for functional cosmetic and medicine.
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KEYWORD
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Antioxidant activity, Cytotoxicity, Euphorbia humifusa, Anti-inflammation
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